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**<font inherit/inherit;;#c0392b;;inherit>Scientific Webinar Calendar:</font> ** [[https://4dnucleome-org.zoom.us/meeting/tJEsc-ytrDksEtWNHy00h-5RmkNx7equ3Nca/ics?icsToken=98tyKuCtrz8vH9aXthGGRowMBY-gZ-_zpnpdj7dqsjf8U3BbL1bEO-lsKuV6Ac2D|click here]] to add all the Scientific Webinar events to your personal calendar | **<font inherit/inherit;;#c0392b;;inherit>Scientific Webinar Calendar:</font> ** [[https://4dnucleome-org.zoom.us/meeting/tJEsc-ytrDksEtWNHy00h-5RmkNx7equ3Nca/ics?icsToken=98tyKuCtrz8vH9aXthGGRowMBY-gZ-_zpnpdj7dqsjf8U3BbL1bEO-lsKuV6Ac2D|click here]] to add all the Scientific Webinar events to your personal calendar | ||
- | <font inherit/inherit;;#c0392b;;inherit>**Scientific Webinar Assignments (2021-2024):**</font> [[http://docs.google.com/spreadsheets/d/122eouLgJtMoCJNKmNhygufdU1qqEy-dDomxqqyQ1TxM/edit?usp=sharing|docs.google.com/spreadsheets/d/122eouLgJtMoCJNKmNhygufdU1qqEy-dDomxqqyQ1TxM/edit?usp=sharing]] | + | <font inherit/inherit;;#c0392b;;inherit>**Scientific Webinar Assignments (2021-2025):**</font> [[http://docs.google.com/spreadsheets/d/122eouLgJtMoCJNKmNhygufdU1qqEy-dDomxqqyQ1TxM/edit?usp=sharing|docs.google.com/spreadsheets/d/122eouLgJtMoCJNKmNhygufdU1qqEy-dDomxqqyQ1TxM/edit?usp=sharing]] |
===== Mission ===== | ===== Mission ===== | ||
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===== Scientific Webinar Series slides presentations ===== | ===== Scientific Webinar Series slides presentations ===== | ||
- | **September 27, 2024** | + | **August 22, 2025** |
- | **Moderator: Yin Shen** | + | **Zoom recording link** |
- | **Presenter: Xiaokun Shu **//(University of California San Francisco)//** - //"Oncoprotein transcription factor MYC undergoes phase separation that differentially modulates the transcriptome" //** ([[https://drive.google.com/file/d/1iK9YUhkQJiFVtiU83NblFyUSE8mj_3_6/view?usp=drive_link|Link to presenter slides]]) | + | **Moderator: Yuan Liu** |
- | **Presenter: Daniel Foltz **//(Northwestern University Feinberg School of Medicine) //**- ****//“Distinct regulation of Histone H1 gene expression within the histone locus body”//** ([[https://docs.google.com/presentation/d/1aJlBpDjYxpu5K8l7tLdaKrUyOyzt51qH/edit?usp=drive_link&ouid=105768913603538088409&rtpof=true&sd=true|Link to presenter slides]]) | + | **Presenter: Jodi Lee **//(University of California, San Francisco) //**-** //**"Predictive modeling to assess the role of 3D genome folding in human congenital heart disease"**// ([[https://drive.google.com/file/d/11mB2tB0l9egVjxAfJckfR3CKb3hy0qxe/view?usp=sharing|Link to presenter slides]]) |
- | * Scientific Webinar presentations (Phase 1) can be found [[https://wiki.4dnucleome.org/4dn:phase1:scientific_webinar_series:scientific_webinar_presentation_archive|here]]. | + | **Presenter: Yanyu Zhu** //(Stanford University) //- **//“High-resolution Dynamic Imaging of Chromatin DNA Communication using Oligo-LiveFISH”//** ([[https://docs.google.com/presentation/d/1o9bXE1ZnWB0bxaXBYzDf1GE14dgzolUx/edit?usp=drive_link&ouid=105768913603538088409&rtpof=true&sd=true|Link to presenter slides]]) |
+ | * Scientific Webinar presentations (Phase 1) can be found [[https://wiki.4dnucleome.org/4dn:phase1:scientific_webinar_series:scientific_webinar_presentation_archive|here]]. | ||
* Scientific Webinar presentations (Phase 2) can be found [[https://wiki.4dnucleome.org/4dn:phase2:scientific_webinar_archive|here]]. | * Scientific Webinar presentations (Phase 2) can be found [[https://wiki.4dnucleome.org/4dn:phase2:scientific_webinar_archive|here]]. | ||
===== 4DN Scientific Webinar Series ===== | ===== 4DN Scientific Webinar Series ===== | ||
- | <font 16px/inherit;;inherit;;inherit>**September 27, 2024**</font> | + | <font 16px/inherit;;inherit;;inherit>**August 22, 2025**</font> |
<font 14px/inherit;;inherit;;inherit>**8:00-8:30 am Pacific Time (20 minute presentation, 10 minute QA)**</font> | <font 14px/inherit;;inherit;;inherit>**8:00-8:30 am Pacific Time (20 minute presentation, 10 minute QA)**</font> | ||
- | {{:4dn:phase2:shu_xiaokun_480.jpg?200|shu_xiaokun_480.jpg}} | + | **Jodi Lee** |
- | **Xiaokun Shu** | + | **Grad Student** |
- | **Professor** | + | [[jodi.lee@gladstone.ucsf.edu|]] |
- | **[[xiaokun.shu@ucsf.edu|]]** | + | **Title: //“Predictive modeling to assess the role of 3D genome folding in human congenital heart disease”// ** |
- | **Title: //“Oncoprotein transcription factor MYC undergoes phase separation that differentially modulates the transcriptome”// ** | + | Jodi is a 4th year graduate student studying genetics in Dr. Katherine Pollard’s Lab at the University of California, San Francisco. Jodi’s research focuses on creating and working with deep learning models to study the complex DNA sequence grammar regulating the genome. Currently, she is leveraging Cardiac-Akita, a DNA sequence to 3D genome folding deep learning model, to predict how genetic variants associated with congenital heart defects disrupt 3D genome contacts. |
- | + | ||
- | Dr. Shu is a Professor at University of California - San Francisco, he loves designing innovative biological tools based on new physical and chemical principles, and applying them to discover new biological principles and therapeutics, including imaging and manipulating cell signaling such as protease and kinase activities, biomolecular condensates, inhibitors of undruggable targets. Prior to start his independent lab at UCSF as an assistant professor in 2010, Dr. Shu conducted postdoc training with Dr. Roger Tsien (Nobel Laureate) at UCSD in Biochemistry from 2007 to 2010, after completing his Ph.D. in Biophysics (Protein Crystallography) at University of Oregon. | + | |
<font 14px/inherit;;inherit;;inherit>**8:30-9:00 am Pacific Time (20 minute presentation, 10 minute QA)**</font> | <font 14px/inherit;;inherit;;inherit>**8:30-9:00 am Pacific Time (20 minute presentation, 10 minute QA)**</font> | ||
- | {{:4dn:phase2:daniel_foltz_720.jpg?200|daniel_foltz_720.jpg}} | + | **Yanyu Zhu** |
- | **Daniel Foltz** | + | **Postdoctoral Researcher** |
- | **Professor** | + | [[yanyuzhu@stanford.edu|]] |
- | **[[dfoltz@northwestern.edu|]]** | + | **Title: //“High-resolution Dynamic Imaging of Chromatin DNA Communication using Oligo-LiveFISH”// ** |
- | **Title: //“Distinct regulation of Histone H1 gene expression within the histone locus body”// ** | + | Yanyu Zhu is a postdoctoral researcher in Prof. Stanley Qi’s Lab in the Department of Bioengineering at Stanford University. He obtained his B.S. in Chemistry from Peking University and his Ph.D. in Chemistry from the University of Wisconsin–Madison. In collaboration with Prof. W. E. Moerner’s lab, he developed and applied a high-resolution, reagent-based DNA imaging platform, Oligo-LiveFISH, to investigate 3D chromatin dynamics in live cells. His current research focuses on applying Oligo-LiveFISH to study various biological questions such as the relationship between the 3D genome and gene regulation in real time, as well as investigating the dynamic process of DNA repair. |
- | + | ||
- | We are part of the Biochemistry and Molecular Genetics Department and Simpson Querrey Epigenetics Institute at Northwestern University Feinberg School of Medicine. Our research program is centered on understanding the dynamics of histone variants and the role of histone chaperones in defining organization of the human genome. We use a variety of genomic and proteomic discovery approaches to define novel pathways that contribute to histone gene expression and deposition. And we seek to understand how the dysfunction of histone metabolism underlies in various disease states. I received my Ph.D. from Northwestern University and conducted my postdoctoral training with Dr. Don Cleveland at UCSD/Ludwig Institute for Cancer Research. | + | |
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- | ===== HOW TO Join the Webinar ===== | + | |
The Webinar Series will be on the **4th Friday of each month from 8am-9am Pacific Time, 11am-12pm Eastern Time.** | The Webinar Series will be on the **4th Friday of each month from 8am-9am Pacific Time, 11am-12pm Eastern Time.** | ||
- | 4DN OH is inviting you to a scheduled Zoom meeting. | + | **4DN OH is inviting you to a scheduled Zoom meeting.** |
Topic: 4DN Scientific Webinar\\ Please download and import the following iCalendar (.ics) files to your calendar system.\\ Monthly: [[https://4dnucleome-org.zoom.us/meeting/tZ0ufu2trzMrG9SNYBoxiO0YxjK3-LEvoHWL/ics?icsToken=98tyKuGhrTIuH9WdsRiHRpx5A4r4LO_zmFxcjfpusibHDDhaTVPPLuhpYf9TNc7f|https://4dnucleome-org.zoom.us/meeting/tZ0ufu2trzMrG9SNYBoxiO0YxjK3-LEvoHWL/ics?icsToken=98tyKuGhrTIuH9WdsRiHRpx5A4r4LO_zmFxcjfpusibHDDhaTVPPLuhpYf9TNc7f]] | Topic: 4DN Scientific Webinar\\ Please download and import the following iCalendar (.ics) files to your calendar system.\\ Monthly: [[https://4dnucleome-org.zoom.us/meeting/tZ0ufu2trzMrG9SNYBoxiO0YxjK3-LEvoHWL/ics?icsToken=98tyKuGhrTIuH9WdsRiHRpx5A4r4LO_zmFxcjfpusibHDDhaTVPPLuhpYf9TNc7f|https://4dnucleome-org.zoom.us/meeting/tZ0ufu2trzMrG9SNYBoxiO0YxjK3-LEvoHWL/ics?icsToken=98tyKuGhrTIuH9WdsRiHRpx5A4r4LO_zmFxcjfpusibHDDhaTVPPLuhpYf9TNc7f]] | ||
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<font 16px/inherit;;inherit;;inherit>**Next Scientific Webinar Presentation**</font> | <font 16px/inherit;;inherit;;inherit>**Next Scientific Webinar Presentation**</font> | ||
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- | **When:October 25, 2024** | ||
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- | **Moderator: Sui Huang** | ||
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- | * Presenter from**Stavros Lomvardas****'s team ** | ||
- | * Presenter from **Ansuman Satpathy****'s** team | ||