===== 4DN Scientific Webinar Series =====

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==== June 26, 2020 ====

//**8:00-8:20 am Pacific Time**//  , 20 minutes talk, then 10 minutes Q&A

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**Karla Neugebauer**

PhD

[[karla.neugebauer@yale.edu|]]

Title: “A Structure-Function Analysis of Cajal Body Assembly ”

Karla Neugebauer holds a BS in Biology from Cornell University, a PhD in Neuroscience from UCSF. She switched gears to RNA biology as a postdoc with Mark Roth at Fred Hutchinson Cancer Research Center. There she participated in the initial description of the SR protein family of splicing regulators and was inspired to study RNA metabolism //in vivo// by combining imaging, genomics, and sequencing strategies. She studied splicing in relation to nuclear speckles and discovered that most introns are removed during the process, or co-transcriptionally. Her lab has shown that snRNP assembly occurs in membraneless organelles called Cajal bodies (CBs) and that depletion of the CB scaffolding protein coilin is lethal in zebrafish embryos, due to a deficit in splicing. She is currently Professor of Molecular Biophysics and Biochemistry and of Cell Biology at Yale University, where she is also Director of the Yale Center for RNA Science and Biomedicine.

//**8:30-8:50 am Pacific Time**//  , 20 minutes talk, then 10 minutes Q&A

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**Charles Danko**

Assistant Professor

[[dankoc@gmail.com|]]

Title: “Focal enhancer-promoter loops: Fact or Fiction”

Charles Danko is the Robert N. Noyce Assistant Professor at Cornell University. His primary research interest is to understand how DNA sequence encodes complex programs of gene expression. Danko played a vital role in developing assays that map the location of RNA polymerase (PRO-seq, ChRO-seq), and has led the development of computational tools which leverage this information to identify active functional elements (dREG). Danko has a long-standing interest in integrating maps of chromatin architecture and transcription to understand the dynamic interactions that encode the timing and levels of gene transcription.o

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===== HOW to Join the webinar: =====

**The 4th Friday of every month, from Friday, January 26, 2018, to no end date\\ 8:00 am | Pacific Daylight Time (San Francisco, GMT-07:00) | 1 hr**\\ \\ Click on this link to connect to the meeting: [[https://4dnucleome.webex.com/4dnucleome/j.php?MTID=md022feb98e8a2583384c2f07114ac51c|https://4dnucleome.webex.com/4dnucleome/j.php?MTID=md022feb98e8a2583384c2f07114ac51c]]

\\ [[https://www.google.com/url?q=https://4dnucleome.webex.com/4dnucleome/j.php?MTID=md022feb98e8a2583384c2f07114ac51c&sa=D&sntz=1&usg=AFQjCNGJDwmlJEEsajUpb8SP9h-2L5XPFA|Join WebEx meeting]]\\ Meeting number: 807 023 120\\ Meeting password: pb9MpJc8\\ Join by phone\\ +1-415-655-0002 US Toll\\ Access code: 807 023 120\\ Add this meeting to your calendar. (Cannot add from mobile devices.)\\ \\ Need help? Go to [[http://help.webex.com/|http://help.webex.com]].

Click on the blue link - Join WebEx Meeting(above, not here) and you will be taken to a new window and asked to write your name and email - then click join. You might need to download the WebEx add on if you never used WebEx before. You will be taken to another window where you should choose call using computer (left circle) then you should be connected.

**During Presentation:**

ATTENDEES, PLEASE:

MUTE YOUR COMPUTER MICROPHONE WHEN JOINING THE WEBINAR

LET THE MODERATOR KNOW THAT YOU HAVE A QUESTION VIA CHAT

QUESTIONS WILL BE ADDRESSED AT THE END OF EACH PRESENTATION, DURING THE DISCUSSION PERIODS.

**In case we experience technical difficulties during the Webinars:**

1. A new WebEx meeting invitation will be sent out immediately to the [[4dn-network@4dnucleome.org|]] email list.

2. If the problem with WebEx persists, OH will notify participants via [[4dn-network@4dnucleome.org|]] email to call [[https://wiki.4dnucleome.org/4dn:1.866.740.1260|1.866.740.1260]] and enter access code 8221626.

3. Participants can find the Scientific Webinar slides presentations above under **Scientific Webinar Series slides presentations.**

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===== Next Scientific Webinar Presentation =====

**When: TBD**

**Moderated by: TBD**

Member from **Center**group** (Presenter: TBD) Member from **Center group** (Presenter: TBD) Member from **Center**group** (Presenter: TBD) Member from **Center group** (Presenter: TBD)