Job Opportunities: 6 job positions are still open. Please check the 4DN Job Advertisement Page for detailed information.
4DN Publications: Please add your preprints into bioRxiv 4DN channel by contacting nils@hms.harvard.edu or leonid@mit.edu. Please also feel free to notify us of your new publications through email: OH@4dnucleome.org or twitter @4DNucleome.
Mayank NK Choudhary, Ryan Z Friedman, Julia T Wang, Hyo Sik Jang, Xiaoyu Zhuo, Ting Wang. Co-opted transposons help perpetuate conserved higher-order chromosomal structures. doi: https://doi.org/10.1101/485342
Recent new publications:
Haifeng Wang, Xiaoshu Xu, Cindy M. Nguyen, Yanxia Liu, Yuchen Gao, Xueqiu Lin, Timothy Daley, Nathan H. Kipniss, Marie La Russa, Lei S. Qi. CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell. 2018 Nov 15;175(5):1405-1417.e14. doi: 10.1016/j.cell.2018.09.013.
Happy New Year 2019!
November 2018
2018 4DN Annual Meeting and 4DN-ASCB Satellite Meeting are coming next week (Dec 4-7). See you in San Diego
Where: The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
Chairs: Dave Gilbert and Yijun Ruan, Vice chairs: Victor Corces and Danny Leung
Job Opportunities: 6 job positions are still open. Please check the 4DN Job Advertisement Page for detailed information.
4DN Publications: Please add your preprints into bioRxiv 4DN channel by contacting nils@hms.harvard.edu or leonid@mit.edu. Please also feel free to notify us of your new publications through email: OH@4dnucleome.org or twitter @4DNucleome.
The Tier 2 cell line mESC G4 provided by University of Washington is available now. Click here to learn more.
Job Opportunities: 6 job positions are still open. Please check the 4DN Job Advertisement Page for detailed information.
4DN Publications: Please add your preprints into bioRxiv 4DN channel by contacting nils@hms.harvard.edu or leonid@mit.edu. Please also feel free to notify us of your new publications through email: OH@4dnucleome.org or twitter @4DNucleome.
Jesse R. Dixon, Jie Xu, Vishnu Dileep, Ye Zhan, Fan Song, Victoria T. Le, Galip Gürkan Yardımcı, Abhijit Chakraborty, Darrin V. Bann, Yanli Wang, Royden Clark, Lijun Zhang, Hongbo Yang, Tingting Liu, Sriranga Iyyanki, Lin An, Christopher Pool, Takayo Sasaki, Juan Carlos Rivera-Mulia, Hakan Ozadam, Bryan R. Lajoie, Rajinder Kaul, Michael Buckley, Kristen Lee, Morgan Diegel, Dubravka Pezic, Christina Ernst, Suzana Hadjur, Duncan T. Odom, John A. Stamatoyannopoulos, James R. Broach, Ross C. Hardison, Ferhat Ay, William Stafford Noble, Job Dekker, David M. Gilbert & Feng Yue. Integrative detection and analysis of structural variation in cancer genomes. Nature Genetics. volume 50, pages1388–1398 (2018). doi: https://doi.org/10.1038/s41588-018-0195-8
Scientific Webinar Series this Month: October 26, 2018
Presenter: Martin Falk (Massachusetts Institute of Technology) - “Heterochromatin drives organization of conventional and inverted nuclei” Link to presenter slides
Presenter: Andrew Barentine (Yale University) - “3D Nanoscopy of 10,000 Nuclei a Day“ Link to presenter slides
September 2018
November 1: Deadline for registration, abstract submission and hotel booking for the 2018 4DN Annual Meeting.
CLICK HERE TO REGISTER
Click here to go the annual meeting wiki page for more information
Job Opportunities: 6 job positions are still open. Please check the 4DN Job Advertisement Page for detailed information.
4DN Publications: Please add your preprints into bioRxiv 4DN channel by contacting nils@hms.harvard.edu or leonid@mit.edu. Please also feel free to notify us of your new publications through email: OH@4dnucleome.org or twitter @4DNucleome.
New preprints in September (bioRxiv 4DN channel):
Sadowski, M., Kraft, A., Szalaj, P., Wlasnowolski, M., Tang, Z., Ruan, Y., Plewczynski, D. Spatial Chromatin Architecture Alteration by Structural Variations in Human Genomes at Population Scale. doi: https://doi.org/10.1101/266981 — Posted: 2018-09-14
Recent new publications:
James H. Sun, Linda Zhou, Daniel J. Emerson, Sai A. Phyo, Katelyn R. Titus, Wanfeng Gong, Thomas G. Gilgenast, Jonathan A. Beagan, Beverly L. Davidson, Flora Tasson, Jennifer E. Phillips-Cremins. Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries. Cell. 2018 Sep 20;175(1):224-238.e15. doi: https://doi.org/10.1016/j.cell.2018.08.005.
Marc A. Marti-Renom, Genevieve Almouzni, Wendy A. Bickmore, Kerstin Bystricky, Giacomo Cavalli, Peter Fraser, Susan M. Gasser, Luca Giorgetti, Edith Heard, Mario Nicodemi, Marcelo Nollmann, Modesto Orozco, Ana Pombo & Maria-Elena Torres-Padilla. Challenges and guidelines toward 4D nucleome data and model standards. Nature Genetics. volume 50, pages1352–1358 (2018). https://doi.org/10.1038/s41588-018-0236-3
Scientific Webinar Series this Month: September 28, 2018
Presenter: Adrien Senecal (Albert Einstein College of Medicine) - The p53 transcription factor regulates transcriptional burst frequency and multiple steps of formation and disruption of chromatin on the p21 gene locus [Link to presenter slides]
Presenter: Matthew Denholtz (University of California, San Diego) - Neutrophil genome dynamics in development and pathogen encounter [Link to presenter slides]
August 2018
Register now for the 2018 4DN Annual Meeting (Dec 5-7, 2018).
CLICK HERE TO REGISTER
Click here to go the annual meeting wiki page for more information
Job Opportunities: 8 job positions are still open. Please check the 4DN Job Advertisement Page for detailed information.
Associate member applications approved (check here to know more)
Maxwell Libbrecht and Michael Hoffman
Kai Tan
4DN Publications: Please add your preprints into bioRxiv 4DN channel by contacting nils@hms.harvard.edu or leonid@mit.edu. Please also feel free to notify us of your new publications through email: OH@4dnucleome.org or twitter @4DNucleome.
New preprints in August (bioRxiv 4DN channel):
Kim, S., Dunham, M., Shendure, J. A combination of transcription factors mediates inducible interchromosomal pairing. doi: https://doi.org/10.1101/385047. Posted: 2018-08-05
Rieger, B., Stallinga, S., Hulleman, C. N., Thorsen, R. O., Grunwald, D., Hammer, M. Photon count estimation in single-molecule localization microscopy. doi: https://doi.org/10.1101/396424. Posted: 2018-08-20
Recent new publications:
Peter Kerpedjiev, Nezar Abdennur, Fritz Lekschas, Chuck McCallum, Kasper Dinkla, Hendrik Strobelt, Jacob M. Luber, Scott B. Ouellette, Alaleh Azhir, Nikhil Kumar, Jeewon Hwang, Soohyun Lee, Burak H. Alver, Hanspeter Pfister, Leonid A. Mirny, Peter J. Park and Nils Gehlenborg. HiGlass: web-based visual exploration and analysis of genome interaction maps. Genome Biology. 2018, Aug 24;19(1):125. doi: https://doi.org/10.1186/s13059-018-1486-1.
Yu Chen, Yang Zhang, Yuchuan Wang, Liguo Zhang, Eva K. Brinkman, Stephen A. Adam, Robert Goldman, Bas van Steensel, Jian Ma, Andrew S. Belmont. Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler. Journal of Cell Biology. August 28, 2018. DOI: https://doi.org/10.1083/jcb.201807108
Won-Ki Cho, Jan-Hendrik Spille, Micca Hecht, Choongman Lee, Charles Li, Valentin Grube, Ibrahim I. Cisse. Mediator and RNA polymerase II clusters associate in transcription-dependent condensates. Science. 27 Jul 2018: Vol. 361, Issue 6400, pp. 412-415. doi: https://doi.org/10.1126/science.aar4199
Shasha Chong, Claire Dugast-Darzacq, Zhe Liu, Peng Dong, Gina M. Dailey, Claudia Cattoglio, Alec Heckert, Sambashiva Banala, Luke Lavis, Xavier Darzacq, Robert Tjian. Imaging dynamic and selective low-complexity domain interactions that control gene transcription. Science 27 Jul 2018:Vol. 361, Issue 6400, eaar2555. doi: https://doi.org/10.1126/science.aar2555
Hongtao Chen, Michal Levo, Lev Barinov, Miki Fujioka, James B. Jaynes & Thomas Gregor. Dynamic interplay between enhancer–promoter topology and gene activity. Nature Genetics. 2018 Volume 50, pages1296–1303. doi: https://doi.org/10.1038/s41588-018-0175-z
Sofia A. Quinodoz, Noah Ollikainen, Barbara Tabak, Ali Palla, Jan Marten Schmidt, Elizabeth Detmar, Mason M. Lai, Alexander A. Shishkin, Prashant Bhat, Yodai Takei, Vickie Trinh, Erik Aznauryan, Pamela Russell, Christine Cheng, Marko Jovanovic, Amy Chow, Long Cai, Patrick McDonel, Manuel Garber, Mitchell Guttman. Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. Cell. 2018, Volume 174, Issue 3, 26, Pages 744-757.e24. doi: https://doi.org/10.1016/j.cell.2018.05.024
Scientific Webinar Series this Month: August 24, 2018
Presenter: Roel Neijts (Institute Pasteur) - Exploring the TAD: specific enhancer-promoter interactions within regulatory domains [Link to presenter slides]
Presenter: Arturas Petronis (Center for Addiction and Mental Health) - Spatiotemporal dynamics of chromatin: the circadian perspective [Link to presenter slides]
July 2018
Register now for the 2018 4DN Annual Meeting (Dec 5-7, 2018).
CLICK HERE TO REGISTER
Click here to go the annual meeting wiki page for more information
The NIH Common Fund 4D Nucleome program has released an RFI to solicit feedback from the national and international community on the remaining challenges towards a comprehensive analysis of the mammalian 4D Nucleome. Suggestions from all are welcome. Written responses must be submitted by August 6, 2018to 4DNucleome@mail.nih.gov.
Textbook seeks inputs and contributors. OH drafted a textbook titled 3D Genome: from technology to visualization, using an E-book format, with college students as the target audience. Please give comments and suggestions by emailing: nucleomebook@4dnucleome.org. Content contributors are welcome!
Job Opportunities: 8 job positions are open. Please check the 4DN Job Advertisement Page for detailed information.
4DN Publications: Please add your preprints into bioRxiv 4DN channel by contacting nils@hms.harvard.edu or leonid@mit.edu. Please also feel free to notify us of your new publications through email: OH@4dnucleome.org or twitter @4DNucleome.
New preprints in July:
Mayuri Rege, Ji Hun Kim, Jacqueline Valeri, Margaret Dunagin, Aryeh Metzger, Wanfeng Gong, Jonathan Beagan, Arjun Raj, Jennifer E Phillips-Cremins. LADL: Light-activated dynamic looping for endogenous gene expression control. doi: https://doi.org/10.1101/349340. Posted June 18, 2018.
New publications in July:
Xiaoyi Cao, Zhangming Yan, Qiuyang Wu, Alvin Zheng and Sheng Zhong. GIVE: portable genome browsers for personal websites. Genome Biology, 2018, 19:92. doi: https://doi.org/10.1186/s13059-018-1465-6
4DN Youtube Channel
3 new videos released on the 4D Nucleome Scientific Webinar Series playlist.
Elucidating the role of nascent RNA at enhancers
Interacting differentially methylated regions (iDMRs) to infer chromosome looping
Trac-looping: a novel technique for analysis of chromatin accessibility and interaction
Scientific Webinar Series this Month: July 27, 2018
Presenter: Tom Pastinen (McGill University) - Interacting differentially methylated regions (iDMRs) to infer chromosome looping
Registration for the 2018 4DN Annual Meeting (Dec 5-7, 2018) is open now.
CLICK HERE TO REGISTER
Click here to go the annual meeting wiki page for more information
Cell line WTC-11 has been moved from a Tier 2 to a Tier 1 cell line, as approved by the Cells WG. We now have 5 cell lines on Tier 1. Check the cell line wiki page for more details.
Upcoming workshops and conferences:
Centromere Biology - 2018 Gordon Research Conference
When: July 29 - August 3, 2018
Where: Mount Snow Resort, West Dover, Vermont, USA
Organizers: Aaron Straight and Sylvia Erhardt
Job Opportunities: Please check the 4DN Job Advertisement Page for detailed information.
2 new job opportunities:
Bioinformatics Scientist – Harvard Medical School - DCIC (Link to details)
Senior Bioinformatics Scientist – Harvard Medical School - DCIC (Link to details)
6 previous job opportunities are still open.
4DN Publications: Please add your preprints into bioRxiv 4DN channel. Please also feel free to notify us of your new publications through email: OH@4dnucleome.org or twitter @4DNucleome.
New preprints in June:
Kim, J., Han, K. Y., Khanna, N., Ha, T., Belmont, A. S. Nuclear speckle fusion via long-range directional motion regulates the number and size of speckles. doi: 10.1101/34795. Posted: 2018-06-15
New publications in June:
Ipek Tasan Gabriela Sustackova Liguo Zhang Jiah Kim Mayandi Sivaguru Mohammad HamediRad Yuchuan Wang Justin Genova Jian Ma Andrew S Belmont, Huimin Zhao. CRISPR/Cas9-mediated knock-in of an optimized TetO repeat for live cell imaging of endogenous loci. Nucleic Acids Research, Published: 15 June 2018. doi: https://doi.org/10.1093/nar/gky501
Ji Hun Kim, Katelyn R.Titus, Wanfeng Gong, Jonathan A. Beagan, Zhendong Cao, Jennifer E.Phillips-Cremins. 5C-ID: Increased resolution Chromosome-Conformation-Capture-Carbon-Copy with in situ 3C and double alternating primer design. Methods, Volume 142, 1 June 2018, Pages 39-46. doi: https://doi.org/10.1016/j.ymeth.2018.05.005
Yang Yang, Quanquan Gu, Yang Zhang, Takayo Sasaki, Julianna Crivello, Rachel J. O'Neill, David M. Gilbert, Jian Ma. Continuous-Trait Probabilistic Model for Comparing Multi-species Functional Genomic Data. Cell Systems. Published Online: June 20, 2018. doi: https://doi.org/10.1016/j.cels.2018.05.022
Weizhong Chen, Zhangming Yan, Simin Li, Norman Huang, Xuerui Huang, Jin Zhang, Sheng Zhong. RNAs as Proximity-Labeling Media for Identifying Nuclear Speckle Positions Relative to the Genome. iScience. Volume 4, p204–215, 29 June 2018. doi: https://doi.org/10.1016/j.isci.2018.06.005
Ruochi Zhang Yuchuan Wang Yang Yang Yang Zhang Jian Ma. Predicting CTCF-mediated chromatin loops using CTCF-MP. Bioinformatics, Volume 34, Issue 13, 1 July 2018, Pages i133–i141. doi: https://doi.org/10.1093/bioinformatics/bty248
Scientific Webinar Series this Month: June 22, 2018
Presenter: Nicola Neretti (Brown University) - Inference and Validation of Chromosomes' 3D Structure
[Link to presenter slides]
Presenter: Andrew Field (Harvard Medical School) - Elucidating the role of nascent RNA at enhancers
Registration for the 2018 4DN Annual Meeting (Dec 5-7, 2018) is open now.
CLICK HERE TO REGISTER
Click here to the annual meeting wiki page for more information
Announcing 4DN Cell Engineering Discussion Group, a forum for making and sharing new engineered cell lines.
Announcing Collaboration plaza, a new wiki page for seeking collaboration opportunities within the 4DN network.
Job Opportunities: 5 job opportunities are still open. Please check detail information on 4DN Job Advertisement page.
4DN Publications
Stats by Apr 30, 2018
Preprints (bioRxiv 4DN channel): 108 in total, 3 new preprints in April
Publications (Pubmed): 156 in total.
New preprints in April:
RNAs as proximity labeling media for identifying nuclear speckle positions relative to the genome. Weizhong Chen, Zhangming Yan, Simin Li, Norman Huang, Xuerui Huang, Jin Zhang, Sheng Zhong. doi: https://doi.org/10.1101/300483
Pattern-Driven Navigation in 2D Multiscale Visual Spaces with Scalable Insets. Fritz Lekschas, Michael Behrisch, Benjamin Bach, Peter Kerpedjiev, Nils Gehlenborg, Hanspeter Pfister. doi: https://doi.org/10.1101/301036
TSA-Seq Mapping of Nuclear Genome Organization. Yu Chen, Yang Zhang, Yuchuan Wang, Liguo Zhang, Eva K. Brinkman, Stephen A. Adam, Robert Goldman, Bas van Steensel, Jian Ma, Andrew S. Belmont. doi: https://doi.org/10.1101/307892
Scientific Webinar Series this Month:
April 27, 2018
Presenter: Karla Neugebauer (Yale University) - The Cell Nucleus under Stress
[Link to presenter slides]
Presenter: Steve Henikoff (Fred Hutchinson Cancer Research Center) - CUT&RUN: Efficient genome-wide profiling of the epigenomic landscape
[Link to presenter slides]
March 2018
Announcing 4DN Cell Engineering Discussion Group, a forum for making and sharing new engineered cell lines.
Announcing Collaboration plaza, a new wiki page for seeking collaboration opportunities within the 4DN network.
New Job Opportunities: Check detail information on 4DN Job Advertisement page
Senior Computational Biologist – The Florida State University (FSU) Center for Genomics (CGPM)
Computational biology postdoc position to analyze chromatin architecture in cancer – Jane Skok and Richard Bonneau New York University School of Medicine and NYU Data Sciences
Postdoc position to study chromatin architecture in cancer: experience in chromosome conformation and capture AND CRISPR preferred – Jane Skok and New York University School of Medicine
Postdoc position to study dynamic chromatin architecture and transcription in developmental systems – Thomas Gregor, Princeton University (USA) and Institut Pasteur (France)
Assistant in Research (12 month salaried, Molecular Biology) – Florida State University Department of Biological Science Core Facility
4DN Publications
Stats by Mar 31, 2018
Preprints (bioRxiv 4DN channel): 105 in total.
Publications (Pubmed): 156 in total. 1 new publication in March, 2018.
Recent publication highlights:
J. H. Gibcus, K.Samejima, L. Goloborodko, I. Samejima, N. Naumova, J. Nuebler, M. T. Kanemaki, L. Xie, J. R. Paulson, W. C. Earnshaw, L. A. Mirny, J. Dekker, A pathway for mitotic chromosome formation. Science 359, eaao6135 (2018).
M. Ganji, I. A.Shaltiel, S. Bisht, E. Kim, A. Kalichava, C. H. Haering, C. Dekker. Real-time imaging of DNA loop extrusion by condensing. Science 359, eaar7831(2018).
4DN Youtube Channel released two new videos from Scientific Webinar Series (Feb 23, 2018).
Paul Fields (University of Washington) - Dynamics of Genome Reorganization during Human Cardiogenesis
Caroline Bartman (University of Pennsylvania) - Frequency modulation of polymerase recruitment via transcriptional bursting is a dominant mode of transcriptional regulation
Scientific Webinar Series this Month:
March 23, 2018
Presenter: Rajarshi P Ghosh (Stanford University) - Chromatin dynamics: Motional signatures of transcriptional state
[Link to presenter slides]
February 2018
Job advertisement page is created on 4DN wiki. Welcome to post job advertisement!
4DN Scientific Webinar Series videos are on 4DN Youtube Channel now.
Scientific Webinar Series this Month: The videos of the two presentations will be released on 4DN Youtube Channel.
February 23, 2018
Presenter: Paul Fields (University of Washington) - Dynamics of Genome Reorganization during Human Cardiogenesis
[Link to presenter slides]
Presenter: Caroline Bartman (University of Pennsylvania) - Frequency modulation of polymerase recruitment via transcriptional bursting is a dominant mode of transcriptional regulation
[Link to presenter slides]
4DN Publications
Stats by Feb 28, 2018
Preprints (bioRxiv 4DN channel): 105 in total, 64 out of them unpublished. 5 new preprints in Feb 2018.
Publications (Pubmed): 155 in total.
Job Opportunities:
Position/Title Employer Job Type Post Date Deadline Status Apply methods / contacts Detail Link
1 Senior Computational Biologist The Florida State University (FSU) Center for Genomics (CGPM) Full-time non-tenure-track Feb 10, 2018 NA Open Online apply Indeed
January 2018
4DN Program Announces Associate Membership. Read the PDF file for more information.
Scientific Webinar Series this Month:
January 26, 2018
Presenter: Yi Kou (University of Southern California) - Mapping genome 3D structure by direct DNA-DNA photo-crosslinking and click enrichment
Presenter: Paul Olivier (University of Toronto) - Developing a new framework to detect and link protein complexes to specific chromatin interactions
Presenter: Meizhen Zheng (The Jackson Laboratory of Genomic Medicine) - Multiplex Chromatin Interaction Analysis with Single Molecule Precision
4dn/phase1/newsletter_archive/newsletter_2018.txt · Last modified: 2025/04/22 16:21 (external edit)