4D Nucleome Network Wiki

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8:00-8:20 am Pacific Time , 20 minutes talk, then 10 minutes Q&A

Karla Neugebauer

PhD

karla.neugebauer@yale.edu

Title: “A Structure-Function Analysis of Cajal Body Assembly ”

Karla Neugebauer holds a BS in Biology from Cornell University, a PhD in Neuroscience from UCSF. She switched gears to RNA biology as a postdoc with Mark Roth at Fred Hutchinson Cancer Research Center. There she participated in the initial description of the SR protein family of splicing regulators and was inspired to study RNA metabolism in vivo by combining imaging, genomics, and sequencing strategies. She studied splicing in relation to nuclear speckles and discovered that most introns are removed during the process, or co-transcriptionally. Her lab has shown that snRNP assembly occurs in membraneless organelles called Cajal bodies (CBs) and that depletion of the CB scaffolding protein coilin is lethal in zebrafish embryos, due to a deficit in splicing. She is currently Professor of Molecular Biophysics and Biochemistry and of Cell Biology at Yale University, where she is also Director of the Yale Center for RNA Science and Biomedicine.

8:30-8:50 am Pacific Time , 20 minutes talk, then 10 minutes Q&A

Charles Danko

Assistant Professor

dankoc@gmail.com

Title: “Focal enhancer-promoter loops: Fact or Fiction”

Charles Danko is the Robert N. Noyce Assistant Professor at Cornell University. His primary research interest is to understand how DNA sequence encodes complex programs of gene expression. Danko played a vital role in developing assays that map the location of RNA polymerase (PRO-seq, ChRO-seq), and has led the development of computational tools which leverage this information to identify active functional elements (dREG). Danko has a long-standing interest in integrating maps of chromatin architecture and transcription to understand the dynamic interactions that encode the timing and levels of gene transcription.o

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The 4th Friday of every month, from Friday, January 26, 2018, to no end date
8:00 am | Pacific Daylight Time (San Francisco, GMT-07:00) | 1 hr

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When: TBD

Moderated by: TBD

Member from Centergroup (Presenter: TBD) Member from Center group (Presenter: TBD) Member from Centergroup (Presenter: TBD) Member from Center group (Presenter: TBD)

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