The 4DN Consortium Scientific Webinar Series is designed to promote sharing ideas and establishment of new collaborations among the consortium members. It features scientific presentations by 4DN member group. These presentations are focused on new discoveries, and new approaches and are not meant to be high-level summaries of deliverables/objectives of each project as in annual consortium meetings. Each group is strongly encouraged to present unpublished research. The PI of each member group may designate either themselves or members of their group to give the presentation.

The format of this webinar series will consist of hour-long online video conferences. In the first round of the Webinar series, 34 presentations are planned. Each Webinar will feature two presentations, with each presentation allocated 20’ of talk time followed by 10’ of discussion. All member groups of 4DN consortium are expected to present once in this round, although some NOFIC centers may present twice given the size of their grants.

In addition to monthly Webinar series, special one-time mini-symposiums may also be added to cover specific topics, as needed, at the discretion of the 4DN Steering Committee.

The Webinar Series will be on the 4th Friday of each Month from 8 am - 9 am Pacific Time, 11 am - 12 pm Eastern Time. The Webinar will consist of two presentations of 30 minutes each (20 minutes presentation, 10 minutes discussion).

The Webinar organization committee has discussed and come up with a schedule for presentations after Feb 2017. See the schedule here: 2017 Webinar Series Presentation Assignments.

The Webinar organization committee has discussed and come up with a schedule for presentations after March 2018. See the schedule here: 2018-2020 Webinar Series Presentation Assignments.

The schedule is ranked by funded project and the corresponding PI's last name. While the corresponding PI is put in the presentation slot, it is up to the corresponding PI to decide who in their team is to give the talk. It is encouraged that trainees are given the chance to present. If the corresponding PI wants to switch with someone else on the list in a mutual agreement, then she/he has the responsibility to arrange it and let the Webinar organization committee know.

Scientific Webinar Committee:

Burak Alver

Andrew Belmont

Jennifer Phillips-Cremins

Bing Ren (chair)

June 26, 2020

Presenter: Karla Neugebauer (Yale University) - “A Structure-Function Analysis of Cajal Body Assembly” (Link to presenter slides)

Presenter: Charles Danko (Cornell University) - “Focal enhancer-promoter loops: Fact or Fiction” (Link to presenter slides)

Previous Scientific Webinar presentations can be downloaded from the Scientific Webinar presentation archive page linked here.

8:00-8:20 am Pacific Time , 20 minutes talk, then 10 minutes Q&A

Karla Neugebauer

karla.neugebauer@yale.edu

Title: “A Structure-Function Analysis of Cajal Body Assembly ”

Karla Neugebauer holds a BS in Biology from Cornell University, a PhD in Neuroscience from UCSF. She switched gears to RNA biology as a postdoc with Mark Roth at Fred Hutchinson Cancer Research Center. There she participated in the initial description of the SR protein family of splicing regulators and was inspired to study RNA metabolism in vivo by combining imaging, genomics, and sequencing strategies. She studied splicing in relation to nuclear speckles and discovered that most introns are removed during the process, or co-transcriptionally. Her lab has shown that snRNP assembly occurs in membraneless organelles called Cajal bodies (CBs) and that depletion of the CB scaffolding protein coilin is lethal in zebrafish embryos, due to a deficit in splicing. She is currently Professor of Molecular Biophysics and Biochemistry and of Cell Biology at Yale University, where she is also Director of the Yale Center for RNA Science and Biomedicine.

8:30-8:50 am Pacific Time , 20 minutes talk, then 10 minutes Q&A

Charles Danko

dankoc@gmail.com

Title: “Focal enhancer-promoter loops: Fact or Fiction”

Charles Danko is the Robert N. Noyce Assistant Professor at Cornell University. His primary research interest is to understand how DNA sequence encodes complex programs of gene expression. Danko played a vital role in developing assays that map the location of RNA polymerase (PRO-seq, ChRO-seq), and has led the development of computational tools which leverage this information to identify active functional elements (dREG). Danko has a long-standing interest in integrating maps of chromatin architecture and transcription to understand the dynamic interactions that encode the timing and levels of gene transcription.

The 4th Friday of every month, from Friday, January 26, 2018, to no end date
8:00 am | Pacific Daylight Time (San Francisco, GMT-07:00) | 1 hr

Click on this link to connect to the meeting: https://4dnucleome.webex.com/4dnucleome/j.php?MTID=md022feb98e8a2583384c2f07114ac51c

Join WebEx meeting
Meeting number: 807 023 120
Meeting password: pb9MpJc8
Join by phone
+1-415-655-0002 US Toll
Access code: 807 023 120
Add this meeting to your calendar. (Cannot add from mobile devices.)

Need help? Go to http://help.webex.com.

Click on the blue link - Join WebEx Meeting(above, not here) and you will be taken to a new window and asked to write your name and email - then click join. You might need to download the WebEx add on if you never used WebEx before. You will be taken to another window where you should choose call using computer (left circle) then you should be connected.

During Presentation:

ATTENDEES, PLEASE:

• MUTE YOUR COMPUTER MICROPHONE WHEN JOINING THE WEBINAR
• LET THE MODERATOR KNOW THAT YOU HAVE A QUESTION VIA CHAT
• QUESTIONS WILL BE ADDRESSED AT THE END OF EACH PRESENTATION, DURING THE DISCUSSION PERIODS.

In case we experience technical difficulties during the Webinars:

1. A new WebEx meeting invitation will be sent out immediately to the 4dn-network@4dnucleome.org email list.

2. If the problem with WebEx persists, OH will notify participants via 4dn-network@4dnucleome.org email to call 1.866.740.1260 and enter access code 8221626.

3. Participants can find the Scientific Webinar slides presentations above under Scientific Webinar Series slides presentations.

When:

Moderated by: TBD

Member from Centergroup (Presenter: TBD) Member from Center group** (Presenter: TBD)