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4DN Scientific Webinar Series
April 27, 2018
8:00-8:20 am Pacific Time, then 10 minutes Q&A
Karla Neugebauer
Professor of Molecular Biophysics and Biochemistry
Yale University
Title: The Cell Nucleus under Stress
Karla Neugebauer is a professor of Molecular Biophysics and Biochemistry at Yale University. Karla obtained her PhD in Neuroscience from UCSF switched gears to RNA biology, when she moved to a postdoc with Mark Roth at Fred Hutchinson Cancer Research Center. There she participated in the initial description of the SR protein family of splicing regulators and was inspired to study RNA metabolism in vivo by combining imaging, genomics, and sequencing strategies. Her lab has shown that snRNP assembly occurs in nuclear compartments, called Cajal bodies (CBs), and that depletion of the CB scaffolding protein coilin is lethal in zebrafish embryos, due to a deficit in splicing. Her lab has also discovered splicing-related pausing in last exons and has shown that splicing rates are tightly matched to transcription. The latter finding indicates that the spliceosome is in close proximity to Pol II during splicing, laying the groundwork for studies of regulation.
8:30-8:50 am Pacific Time, then 10 minutes Q&A
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Steve Henikoff
Principal Investigator (TCPA)
Fred Hutchinson Cancer Research Center
Title:
CUT&RUN: Efficient genome-wide profiling of the epigenomic landscape
Steven Henikoff is a member of the Basic Sciences Division at the Fred Hutchinson Cancer Research Center and an investigator of the Howard Hughes Medical Institute. He performs research on chromatin dynamics, transcriptional regulation, and centromere maintenance and develops experimental and computational tools for studying these processes. Recent methods map nucleosome turnover, transcription factors, DNA torsion and nascent chromatin landscapes genome-wide at high resolution. Application of these tools has elucidated the relationship between transcription, torsion, and nucleosome turnover, identified the nucleosome barrier to transcription, revealed a competition between nucleosomes and transcription factors behind the replication fork and during transcription, and determined the molecular organization of centromeric nucleosomes.
HOW to Join the webinar:
Join by phone
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Click on the blue link - Join WebEx Meeting (above, not here) and you will be taken to a new window and asked to write your name and email - then click join. You might need to download the WebEx add on if you never used WebEx before. You will be taken to another window where you should choose call using computer (left circle) then you should be connected.
During Presentation:
ATTENDEES, PLEASE:
- MUTE YOUR COMPUTER MICROPHONE WHEN JOINING THE WEBINAR
- LET THE MODERATOR KNOW THAT YOU HAVE A QUESTION VIA CHAT
- QUESTIONS WILL BE ADDRESSED AT THE END OF EACH PRESENTATION, DURING THE DISCUSSION PERIODS.
In case we experience technical difficulties during the Webinars:
1. A new WebEx meeting invitation will be sent out immediately to the 4dn-network@4dnucleome.org email list.
2. If the problem with WebEx persists, OH will notify participants via 4dn-network@4dnucleome.org email to call 1.866.740.1260 and enter access code 8221626
3. Participants can find the Scientific Webinar slides presentations above under Scientific Webinar Series slides presentations.
Next Scientific Webinar Presentation
When: May 25, 2018
Moderated by: Jennifer Philips-Cremins
Member from Wouter de Laat's group (Presenter and title will be determined by the group)
Member from Brad Cair's group (Presenter and title will be determined by the group)