4DN Google Drive folder: https://drive.google.com/drive/folders/1Q1mzBETKDLLnMviloMVGCieBNNqKbP36?usp=sharing

Scientific Webinar Calendar: click here to add all the Scientific Webinar events to your personal calendar

Scientific Webinar Assignments (2021-2024): docs.google.com/spreadsheets/d/122eouLgJtMoCJNKmNhygufdU1qqEy-dDomxqqyQ1TxM/edit?usp=sharing

The 4DN Consortium Scientific Webinar Series is designed to promote sharing ideas and establishment of new collaborations among the consortium members. It features scientific presentations by 4DN member group. These presentations are focused on new discoveries, and new approaches and are not meant to be high-level summaries of deliverables/objectives of each project as in annual consortium meetings. Each group is strongly encouraged to present unpublished research. The PI of each member group may designate either themselves or members of their group to give the presentation.

The format of this webinar series will consist of hour-long online video conferences. Each Webinar will feature two presentations, with each presentation allocated 20’ of talk time followed by 10’ of discussion. All member groups of 4DN consortium are expected to present once in this round, although some centers may present twice given the size of their grants.

The Webinar organization committee has discussed and come up with a schedule for presentations after February 2021. See the schedule here: Scientific Webinar Assignment 2021-2024.

The schedule is ranked by funded project and the corresponding PI's last name. While the corresponding PI is put in the presentation slot, it is up to the corresponding PI to decide who in their team is to give the talk. It is encouraged that trainees are given the chance to present. If the corresponding PI wants to switch with someone else on the list in a mutual agreement, then she/he has the responsibility to arrange it and let the Webinar organization committee know.

Scientific Webinar Committee: Ana Pombo, Golnaz Vahedi, Sheng Zhong, Ting Wang, Wenbo Li, Sui Huang, Yin Shen, Taekjip Ha

March 26, 2021

Presenter: Andrew Stephens (University of Massachusetts) - “HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics” (Link to presenter slides)

Presenter: Chenxiang Qiu (University of Washington) - “Systematic reconstruction of the cellular trajectories of mammalian embryogenesis” (Link to presenter slides)

• Scientific Webinar presentations (Phase 1) can be found here.
• Scientific Webinar presentations (Phase 2) can be found here.

March 26, 2021

8:00-8:20 am Pacific Time, 20 minutes talk, then 10 minutes Q&A

Andrew Stephens

Ph.D.

andrew.stephens@umass.edu

Title: “HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics”

In my graduate work with Kerry Bloom at UNC, I studied the pericentromeric chromatin spring in mitosis which is where I first started to think about chromatin as a mechanical element and spring. During my Postdoc work with John Marko at Northwestern University I developed a micromanipulation of micropipettes technique to isolate and measure the force response of a single cell nucleus which uncovered the separate roles of chromatin (dominating short extension) and lamin A (strain stiffening at long extensions). In 2020 I stated my own lab as an Assistant Professor at UMass Amherst where we continue to study the mechanical role of chromatin in the interphase nucleus which directly impacts nuclear shape and function.

8:30-8:50 am Pacific Time, 20 minutes talk, then 10 minutes Q&A

Chenxiang Qiu

PhD

cxqiu@uw.edu

Title: “Systematic reconstruction of the cellular trajectories of mammalian embryogenesis”

Chengxiang Qiu is a PhD candidate in the lab of Dr. Jay Shendure at the University of Washington. He is interested in applying computational and statistical methods on single cell profiling of gene expression and chromatin accessibility towards obtaining global views of development.

The Webinar Series will be on the 4th Friday of each month from 8am-9am Pacific Time, 11am-12pm Eastern Time.

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During Presentation:

ATTENDEES, PLEASE:

• MUTE YOUR COMPUTER MICROPHONE WHEN JOINING THE WEBINAR

• LET THE MODERATOR KNOW THAT YOU HAVE A QUESTION VIA CHAT

• QUESTIONS WILL BE ADDRESSED AT THE END OF EACH PRESENTATION, DURING THE DISCUSSION PERIODS

Next Scientific Webinar Presentation

When: April 23, 2021

Moderator: Ting Wang

Presenters:

• Member from Jesse Dixon's group (Presenter and title will be determined by group)
• Member from Yarui Diao's group (Presenter and title will be determined by group)