4DN Google Drive folder: https://drive.google.com/drive/folders/1Q1mzBETKDLLnMviloMVGCieBNNqKbP36?usp=sharing

Scientific Webinar Calendar: click here to add all the Scientific Webinar events to your personal calendar

Scientific Webinar Assignments (2021-2024): docs.google.com/spreadsheets/d/122eouLgJtMoCJNKmNhygufdU1qqEy-dDomxqqyQ1TxM/edit?usp=sharing

The 4DN Consortium Scientific Webinar Series is designed to promote sharing ideas and establishment of new collaborations among the consortium members. It features scientific presentations by 4DN member group. These presentations are focused on new discoveries, and new approaches and are not meant to be high-level summaries of deliverables/objectives of each project as in annual consortium meetings. Each group is strongly encouraged to present unpublished research. The PI of each member group may designate either themselves or members of their group to give the presentation.

The format of this webinar series will consist of hour-long online video conferences. Each Webinar will feature two presentations, with each presentation allocated 20’ of talk time followed by 10’ of discussion. All member groups of 4DN consortium are expected to present once in this round, although some centers may present twice given the size of their grants.

The Webinar organization committee has discussed and come up with a schedule for presentations after February 2021. See the schedule here: Scientific Webinar Assignment 2021-2024.

The schedule is ranked by funded project and the corresponding PI's last name. While the corresponding PI is put in the presentation slot, it is up to the corresponding PI to decide who in their team is to give the talk. It is encouraged that trainees are given the chance to present. If the corresponding PI wants to switch with someone else on the list in a mutual agreement, then she/he has the responsibility to arrange it and let the Webinar organization committee know.

Scientific Webinar Committee: Ana Pombo, Golnaz Vahedi, Sheng Zhong, Ting Wang, Wenbo Li, Sui Huang, Yin Shen, Taekjip Ha

March 24, 2023

Moderator: Sui Huang

Presenter: Meng Xu (Carnegie Mellon University) - “TERRA-LSD1 condensates promote R-loop formation for telomere maintenance in ALT cancer cells” (Link to presenter slides)

Presenter: Yarui Diao (Duke University) - “Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells” (Link to presenter slides)

• Scientific Webinar presentations (Phase 1) can be found here.

• Scientific Webinar presentations (Phase 2) can be found here.

March 24, 2023

8:00-8:30 am Pacific Time (20 minute presentation, 10 minute QA)

Meng XU

Postdoctoral Fellow

mengx@andrew.cmu.edu

Title: “TERRA-LSD1 condensates promote R-loop formation for telomere maintenance in ALT cancer cells”

Dr. Meng Xu earned his Ph.D. degree from the Institute of Genetics and Developmental Biology (IGDB), Chinese Academy of Sciences (CAS) in 2016. Currently, he is working as a postdoctoral fellow in Prof. Huaiying Zhang's lab at Carnegie Mellon University. His current research focuses on the formation of protein-protein or protein-RNA condensates by phase transition and their biological roles in physiological and pathological conditions.

8:30-9:00 am Pacific Time (20 minute presentation, 10 minute QA)

Yarui Diao

Assistant Professor

yarui.diao@duke.edu

Title: “Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells”

Yarui earned his PhD in Biochemistry under the guidance of Dr. Zhenguo Wu in 2011 from the Hong Kong University of Science and Technology. During his graduate studies, he focused primarily on the transcription and epigenetic regulation of skeletal muscle regeneration. Following his PhD, Yarui pursued postdoctoral training in gene regulation under the mentorship of Dr. Bing Ren at UC San Diego as a Human Frontier Science Program (HFSP) fellow. During this time, he expanded his knowledge of gene regulation and developed a strong interest in genomics. In 2018, Yarui established his independent research program, “Regeneration Genomics,” at Duke Cell Biology, where he investigates gene regulation of tissue regeneration in injury and diseases. His lab is dedicated to developing innovative genomics tools and applying genomics technologies to study stem cell biology tissue regeneration in health and disease.

The Webinar Series will be on the 4th Friday of each month from 8am-9am Pacific Time, 11am-12pm Eastern Time.

4DN OH is inviting you to a scheduled Zoom meeting.

Topic: 4DN Scientific Webinar
Please download and import the following iCalendar (.ics) files to your calendar system.
Monthly: https://4dnucleome-org.zoom.us/meeting/tZ0ufu2trzMrG9SNYBoxiO0YxjK3-LEvoHWL/ics?icsToken=98tyKuGhrTIuH9WdsRiHRpx5A4r4LO_zmFxcjfpusibHDDhaTVPPLuhpYf9TNc7f

Join Zoom Meeting
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Meeting ID: 893 9451 8110
Passcode: 049455
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During Presentation:

ATTENDEES, PLEASE:

• MUTE YOUR COMPUTER MICROPHONE WHEN JOINING THE WEBINAR

• LET THE MODERATOR KNOW THAT YOU HAVE A QUESTION VIA CHAT

• QUESTIONS WILL BE ADDRESSED AT THE END OF EACH PRESENTATION, DURING THE DISCUSSION PERIODS

Next Scientific Webinar Presentation

When: April 28, 2023

Moderator: Yin Shen

• Presenter from Sheng Zhong's team
• Presenter from Jennifer Phillips-Cremins (contact), Gerd Blobel, Lei Stanley Qi, Arjun Raj's team