4DN Google Drive folder: https://drive.google.com/drive/folders/1Q1mzBETKDLLnMviloMVGCieBNNqKbP36?usp=sharing

Scientific Webinar Calendar: click here to add all the Scientific Webinar events to your personal calendar

Scientific Webinar Assignments (2021-2025): docs.google.com/spreadsheets/d/122eouLgJtMoCJNKmNhygufdU1qqEy-dDomxqqyQ1TxM/edit?usp=sharing

The 4DN Consortium Scientific Webinar Series is designed to promote sharing ideas and establishment of new collaborations among the consortium members. It features scientific presentations by 4DN member group. These presentations are focused on new discoveries, and new approaches and are not meant to be high-level summaries of deliverables/objectives of each project as in annual consortium meetings. Each group is strongly encouraged to present unpublished research. The PI of each member group may designate either themselves or members of their group to give the presentation.

The format of this webinar series will consist of hour-long online video conferences. Each Webinar will feature two presentations, with each presentation allocated 20’ of talk time followed by 10’ of discussion. All member groups of 4DN consortium are expected to present once in this round, although some centers may present twice given the size of their grants.

The Webinar organization committee has discussed and come up with a schedule for presentations after February 2021. See the schedule here: Scientific Webinar Assignment 2021-2024.

The schedule is ranked by funded project and the corresponding PI's last name. While the corresponding PI is put in the presentation slot, it is up to the corresponding PI to decide who in their team is to give the talk. It is encouraged that trainees are given the chance to present. If the corresponding PI wants to switch with someone else on the list in a mutual agreement, then she/he has the responsibility to arrange it and let the Webinar organization committee know.

Scientific Webinar Committee: Ana Pombo, Golnaz Vahedi, Sheng Zhong, Ting Wang, Wenbo Li, Sui Huang, Yin Shen, Taekjip Ha

July 25, 2025

Zoom recording link

Moderator: Sui Huang

Presenter: Han Yang (University of California, San Francisco) - “ Functional Characterization of Schizophrenia Risk Variants Using PRIME Editing in Excitatory Neurons ” (Link to presenter slides)

Presenter: Nathan Zemke (University of California San Diego) - “ Epigenetic and 3D genome reprogramming during the aging of human hippocampus ” (Link to presenter slides)

• Scientific Webinar presentations (Phase 1) can be found here.
• Scientific Webinar presentations (Phase 2) can be found here.

July 25, 2025

8:00-8:30 am Pacific Time (20 minute presentation, 10 minute QA)

Han Yang

Postdoctoral fellow

Han.Yang@ucsf.edu

Title: “Functional Characterization of Schizophrenia Risk Variants Using PRIME Editing in Excitatory Neurons”

Han Yang is a postdoctoral fellow in the Yin Shen Lab at the University of California, San Francisco. He earned his Ph.D. in Molecular Pathology from Peking University Health Science Center. Han's research focuses on developing and applying cutting-edge functional genomics tools to study the role of genetic variants in complex disease. Currently, he is leveraging the PRIME editing screens he co-developed to investigate how both common and rare schizophrenia risk variants affect excitatory neurons.

8:30-9:00 am Pacific Time (20 minute presentation, 10 minute QA)

NathanZemke

Director of Single Cell Genomics at the Center for Epigenomic

nzemke@health.ucsd.edu

Title: “Epigenetic and 3D genome reprogramming during the aging of human hippocampus”

Nathan is Director of Single Cell Genomics at the Center for Epigenomics at UCSD. He explores principles of gene regulation in the context of chromatin organization from mammalian tissues. His work involves identifying functional cis-regulatory elements and mapping cell-type resolved chromatin architecture from complex mammalian tissue using multi-omic single-cell technologies.

The Webinar Series will be on the 4th Friday of each month from 8am-9am Pacific Time, 11am-12pm Eastern Time.

4DN OH is inviting you to a scheduled Zoom meeting.

Topic: 4DN Scientific Webinar
Please download and import the following iCalendar (.ics) files to your calendar system.
Monthly: https://4dnucleome-org.zoom.us/meeting/tZ0ufu2trzMrG9SNYBoxiO0YxjK3-LEvoHWL/ics?icsToken=98tyKuGhrTIuH9WdsRiHRpx5A4r4LO_zmFxcjfpusibHDDhaTVPPLuhpYf9TNc7f

Join Zoom Meeting
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Meeting ID: 893 9451 8110
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During Presentation:

ATTENDEES, PLEASE:

• MUTE YOUR COMPUTER MICROPHONE WHEN JOINING THE WEBINAR

• LET THE MODERATOR KNOW THAT YOU HAVE A QUESTION VIA CHAT

• QUESTIONS WILL BE ADDRESSED AT THE END OF EACH PRESENTATION, DURING THE DISCUSSION PERIODS

Next Scientific Webinar Presentation

When: August 22, 2025

Moderator: Taekjip Ha

• Presenter from Benoit Bruneau (contact), Katherine Pollard's team
• Presenter from Jennifer Phillips-Cremins (contact), Gerd Blobel, Lei Stanley Qi, Arjun Raj's team