Point people/organizers: Frank Alber, Bing Ren, Yin Shen, Susanne Rafelski

4DN Google Drive folder: https://drive.google.com/drive/folders/1sskUxIcdm9Aohp92XeNwv9wt6nNYR3U2?usp=sharing

4DN Calendar: https://wiki.4dnucleome.org/4dn:calendar_4dn (click here to add this specific WG calendar to your personal calendar)

Agenda/minutes: https://docs.google.com/document/d/1-cgXP2sBcvZMT-Ap5Z5wzSYteRJnyAvQTsShsu9Wgw0/edit?usp=sharing

Meeting attendee spreadsheet: https://docs.google.com/spreadsheets/d/1pUjpEu0NoodCX4pHtf4lYxJn2DdhVWxwrThaiHYUy2o/edit?usp=sharing

Email list: wtc-11@4dnucleome.org

Slack channel: #wg-integrating-imaging-omics

Landing page at the 4DN portal: https://data.4dnucleome.org/4DN-AICS-Collaboration

The working group’s efforts will be devoted to developing an integrative framework for combining various imaging modalities—in particular live-cell imaging—with single cell and ensemble genomics data to study the changes in global cellular organization during biological processes, such as cell cycle, differentiation or perturbations. An explicit goal of this working group is to provide a platform and foster interactions between researchers from different disciplines—imaging, genomics and computational modeling—to work jointly on this common goal. The working group will develop strategies for data integration, common practices and potentially coordinate joint efforts in data generation for the benefit of a joint project.

The working group is a continuation of an effort in phase 1, which focused on WTC11 cells as a target system to integrate live-cell imaging with genomics data for studying the temporal dimension of 3D genome organization.The goal was to understand the principles by which cells reorganize in 3D space as they move from state to state in response to the cell cycle, differentiation, or changes in environment. Although WTC11 will still be a primary target, the working group will foster all projects devoted to the integration of live-cell and other imaging modalities with omicsdata.