• February 28, 2020 Click to see archived announcements

• January 24, 2020 Click to see archived announcements

Presenter: Leo Barinov (Princeton University) - “Interplay between chromatin organization and transcriptional activity” (Link to presenter slides)

Presenter: Mathias Hammer (Humboldt University of Berlin) - “A study on effects of fixation with Formaldehyde and Paraformaldehyde” (Link to presenter slides)

• October 25, 2019 Click to see archived announcements

Presenter: Nimrod Rappoport (Weizman Institute of Science) - “Single cell Hi-C and dissection of replication landscapes and chromosomal organization in mouse embryonic lineages” (Link to presenter slides)

Presenter: Kanishk Abhinav (The University of Edinburgh) - “Local environment of inner nuclear membrane proteins analyzed by proximity labeling and mass spectrometry” (Link to presenter slides)

• September 27, 2019 Click to see archived announcements

Presenter: Joshua Riback (Princeton University) - “Composition dependent phase separation underlies directional flux through the nucleolus” (Link to presenter slides)

Presenter: Jian Ma (School of Computer Science at Carnegie Mellon University) - “Multimodal, interactive data visualization and exploration for the 4D Nucleome” (Link to presenter slides)

• August 23, 2019 Click to see archived announcements

Presenter: Andrew Stephens (Umass Amherst) - “Heterochromatin and HP1alpha provide different nuclear mechanical contributions to maintain nuclear shape and function” (Link to presenter slides)

Presenter: Yodai Takei (Caltech) - “Intron seqFISH enables spatial analysis of the nascent transcriptome in single cells” (Link to presenter slides)

• July 26, 2019 Click to see archived announcements

Presenter: Mary Arrastia (California Institute of Technology) - “Studying the structural organization of subnuclear chromatin compartments through genome structure modeling” (Link to presenter slides)

Presenter: Yanxiao Zhang (Ludwig Institute for Cancer Research San Diego) - “Transcriptionally Active HERV-H Retrotransposons Demarcate TADs in Human ESCs” (Link to presenter slides)

• June 28, 2019 Click to see archived announcements

Presenter: Asli Yildirim (University of California, Los Angeles) - “Studying the structural organization of subnuclear chromatin compartments through genome structure modeling” (Link to presenter slides)

Presenter: Anastassiia Vertii (University of Massachusetts Medical School) - “The composition and regulation of nucleolus-associated domains” (Link to presenter slides)

• May 24, 2019 Click to see archived announcements

Presenter: Molly Gasperini (University of Washington) - “Pairing enhancers with their target genes via multiplexed cellular genetic screens” (Link to presenter slides)

Presenter: Mayank NK Choudhary (Washington Univeristy) - “Co-opted transposons help perpetuate conserved higher-order chromosomal structures” (Link to presenter slides)

• April 26, 2019 Click to see archived announcements

Presenter: Soohyun Lee (Harvard Medical School) - “Reproducible Data Processing at the 4DN Data Coordination and Integration Center” [Link to presenter slides]

Presenter: Jonas Ries (EMBL) - “Nuclear pores as versatile reference standards for quantitative microscopy” (Link to presenter slides)

• February 22, 2019 Click to see archived announcements

Presenter: Haoyue (Adam) Zhang (Children's Hospital of Philadelphia) - “Re-configuration of Chromatin Structure During the Mitosis-G1 Phase Transition” (Link to presenter slides)

Presenter: Bas van Steensel (Netherlands Cancer Institute) - “Rewiring LADs by transcription” Link to presenter slides

• January 25, 2019 Click to see archived announcements

Presenter: John Rinn (University of Minnesota) - “Crispr Live Cell imaging (CLING) and HiC data: insights into CTCF, RNA and TAD Boundaries” (Link to presenter slides)

Presenter: Daniel Capurso (The Jackson Laboratory for Genomic Medicine) - “ChIA-PIPE, a robust computational pipeline for ChIA-PET and related 3D genome mapping data” (Link to presenter slides)

• October 26, 2018 Click to see archived announcements

Presenter: Martin Falk (Massachusetts Institute of Technology) - “Heterochromatin drives organization of conventional and inverted nuclei” (Link to presenter slides)

Presenter: Andrew Barentine (Yale University) - “3D Nanoscopy of 10,000 Nuclei a Day“ (Link to presenter slides)

• September 28, 2018 Click to see archived announcements

Presenter: Adrien Senecal (Albert Einstein College of Medicine) - “The p53 transcription factor regulates transcriptional burst frequency and multiple steps of formation and disruption of chromatin on the p21 gene locus” (Link to presenter slides)

Presenter: Matthew Denholtz (University of California, San Diego) - “Neutrophil genome dynamics in development and pathogen encounter” (Link to presenter slides)

• August 24, 2018 Click to see archived announcements

Presenter: Roel Neijts (Institute Pasteur) - “Exploring the TAD: specific enhancer-promoter interactions within regulatory domains” (Link to presenter slides)

Presenter: Arturas Petronis (Center for Addiction and Mental Health) - “Spatiotemporal dynamics of chromatin: the circadian perspective“ (Link to presenter slides)

• July 27, 2018 Click to see archived announcements

Presenter: Tom Pastinen (McGill University) - “Interacting differentially methylated regions (iDMRs) to infer chromosome looping” (Link to presenter slides)

Presenter: Keji Zhao (NHLBI) - “Trac-looping: a novel technique for analysis of chromatin accessibility and interaction” (Link to presenter slides)

• June 22, 2018 Click to see archived announcements

Presenter: Nicola Neretti (Brown University) - Inference and Validation of Chromosomes' 3D Structure (Link to presenter slides)

Presenter: Andrew Field (Harvard Medical School) - Elucidating the role of nascent RNA at enhancers (Link to presenter slides)

• May 25, 2018 Click to see archived announcements

Presenter: Wouter de Laat (Hubrecht Institute) - Enhancer hubs and loop collisions identified from single-allele topologies - (Link to presenter slides)

Presenter: Brad Cairns (University of Utah) - How the Genome Awakens in Zebrafish (Link to presenter slides)

• April 27, 2018 Click to see archived announcements

Presenter: Karla Neugebauer (Yale University) - The Cell Nucleus under Stress (Link to presenter slides)

Presenter: Steve Henikoff (Fred Hutchinson Cancer Research Center) - CUT&RUN: Efficient genome-wide profiling of the epigenomic landscape (Link to presenter slides)

• March 23, 2018 Click to see archived announcements

Presenter: Rajarshi P Ghosh (Stanford University) - Chromatin dynamics: Motional signatures of transcriptional state (Link to presenter slides)

• February 23, 2018 Click to see archived announcements

Presenter: Paul Fields (University of Washington) - Dynamics of Genome Reorganization during Human Cardiogenesis (Link to presenter slides)

Presenter: Caroline Bartman (University of Pennsylvania) - Frequency modulation of polymerase recruitment via transcriptional bursting is a dominant mode of transcriptional regulation (Link to presenter slides)

• January 26, 2018 Click to see archived announcements

Presenter: Yi Kou (University of Southern California) - Mapping genome 3D structure by direct DNA-DNA photo-crosslinking and click enrichment (Link to presenter slides)

Presenter: Paul Olivier (University of Toronto) - Developing a new framework to detect and link protein complexes to specific chromatin interactions(Link to presenter slides)

Presenter: Meizhen Zheng (The Jackson Laboratory of Genomic Medicine) - Multiplex Chromatin Interaction Analysis with Single Molecule Precision (Link to PDF of presenter slides)

• October 27, 2017 Click to see archived announcements

Presenter: Adan Horta (Columbia University) - Interchromsomal Interactions as a Source of Neuronal Diversity (Link to presenter slides)

Presenter: Horng Ou (UCSF) - Visualizing chromatin ultrastructure in interphase and mitotic cells by ChromEMT (Link to PDF of presenter slides)

• August 25, 2017 Click to see archived announcements

Presenter: Kit S Lam (University of California Davis) - The use of OBOC combinatorial library method to discover Genetically Encoded Small Illuminants for cellular imaging (Link to presenter slides)

Presenter: Suhas Rao (Stanford University) - Tracking the 4D nucleome during cohesin loss and recovery (Link to PDF of presenter slides)

• July 28, 2017 Click to see archived announcements

Presenter: Rupesh Amin (Juno Therapeutics) - Engineering a Tethering System to Dissect Gene Regulation in Mouse Embryonic Stem Cells (Link to presenter slides)

Presenter: Maximiliaan Huisman (University of Massachusetts Medical School) - Cryo-FM: moving towards single-basepair resolution in fluorescence microscopy (Link to PDF of presenter slides)

• June 23, 2017 Click to see archived announcements

Presenter: Cory Lindsay (The Scripps Research Institute) - Analysis of the nuclear lamina by proteomics and proximity labeling (Link to presenter slides)

Presenter: Takashi Fukaya (Princeton University) - Visualization of trans-homologue enhancer-promoter interaction in living Drosophila embryos (Link to PDF of presenter slides)

• May 26th, 2017 Click to see archived announcements

Presenter: Vishnu Dileep (Florida State University) - Measuring genome-wide replication timing in single cells (Link to PDF of presenter slides)

Presenter: Yaniv Lubling (Weizmann Institute of Science, Israel) - Cell cycle dynamics of chromosomal organisation at single-cell resolution (Link to PDF of presenter slides)

• April 28th, 2017 Click to see archived announcements

Presenter: Yongdae Shin (Princeton University) - Optical control of intracellular phase transitions (Link to PDF of presenter slides)

Presenter: Yodai Takei (Caltech) - Multiplexed dynamic imaging of genomic loci by combined CRISPR imaging and DNA sequential FISH (Link to PDF of presenter slides)

• March 24th, 2017 Click to see archived announcements

Presenter: Naoki Kubo (UCSD) - High-resolution mapping of nucleolar-associated chromatin in mouse cells (Link to PDF of presenter slides)

Presenter: Anders Sejr Hansen (UC Berkeley) - CTCF and cohesin regulate chromatin loop stability with distinct dynamics (Link to PDF of presenter slides)

• February 24th, 2017 Click to see archived announcements

Presenter: Anastassia Vertii (UMASS) - High-resolution mapping of nucleolar-associated chromatin in mouse cells (Link to presenter slides)

Presenter: Sofia Quinodoz (CalTech) - Mapping RNA and DNA in higher-order nuclear structures (Link to PDF of presenter slides)

• January 27th, 2017

Presenter: Ewan Birney - ChromoTrace: Simulation and reconstruction of 3D chromosome configuration by super-resolution microscopy. (Link to PDF of presenter slides)

Presenter: Nan Hua - 3D genome structure calculation by data integration (Link to PDF of presenter slides)

Due to holidays observance, there will be no Scientific Seminar Series in November and December.

• October 28th, 2016

Presenter: Tao Yang - HiCRep: measuring the reproducibility of Hi-C data. Link to PDF of presenter slides

Presenter: Xinxian Deng - Role of Dxz4 in the 3D bipartite structure of the inactive X chromosome. Link to presenter slides

• September 23rd, 2016

Presenter: Yu Chen - Mapping Intranuclear Chromosome Position with TSA-Seq. Link to PDF of presenter slides

Presenter: Peter Kerpedjiev - HiGlass: Multi-resolution online HiC data display. Link to presenter slides

• August 26th, 2016

Presenter: Zhonghui Tang (Ruan Lab, JAX) - “Haplotype-specific chromatin interactions” Link to PDF of presenter slides

Presenter: Jennifer Phillips-Cremins - “Genome reconfiguration during somatic cell reprogramming”. Link to PDF of presenter slides

• July 22nd, 2016

Presenter: Mitchell Guttman - “How a lncRNA shapes nuclear structure to regulate gene expression” (Link to PDF of presenter slides)

• June 24th, 2016

Presenter: Job Dekker - Title: “Expansion HiC?”. Link to PDF of presenter slides

Presenter: Joerg Bewersdorf - Title: “Ultra-high resolution 3D fluorescence imaging of whole mammalian cells (and nuclei)”. Link to PDF of presenter slides